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U0126, an Inhibitor of MEK1/2, Increases Tumor Necrosis Factor-α-Induced Apoptosis, but not Interleukin-6 Induced Apoptosis in C-28/I2 Human Chondrocytes

BACKGROUND: Activation of the SAPK/MAPK signaling pathway by pro-inflammatory cytokines is known to induce apoptosis in cultured articular chondrocytes. C-28/I2, an immortalized human juvenile chondrocyte cell line was employed to determine the extent to which recombinant human (rh) forms of the pro...

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Detalhes bibliográficos
Publicado no:J Autoimmune Disord
Main Authors: Malemud, Charles J, Lewis, Aaron C, Wylie, Meredith A, Meszaros, Evan C, Skomorovska-Prokvolit, Yelenna, Mesiano, Sam
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739803/
https://ncbi.nlm.nih.gov/pubmed/26855970
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