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Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins
Using a new bioinformatic method to analyze ribosome profiling data, we show that 40% of lncRNAs and pseudogene RNAs expressed in human cells are translated. In addition, ~35% of mRNA coding genes are translated upstream of the primary protein-coding region (uORFs) and 4% are translated downstream (...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4739776/ https://ncbi.nlm.nih.gov/pubmed/26687005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08890 |
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