Transmembrane chemokines act as receptors in a novel mechanism termed inverse signaling

The transmembrane chemokines CX3CL1/fractalkine and CXCL16 are widely expressed in different types of tumors, often without an appropriate expression of their classical receptors. We observed that receptor-negative cancer cells could be stimulated by the soluble chemokines. Searching for alternative...

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Vydáno v:eLife
Hlavní autoři: Hattermann, Kirsten, Gebhardt, Henrike, Krossa, Sebastian, Ludwig, Andreas, Lucius, Ralph, Held-Feindt, Janka, Mentlein, Rolf
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739769/
https://ncbi.nlm.nih.gov/pubmed/26796342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10820
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