MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

Fibrosis of organs is observed in systemic autoimmune disease. Using a scleroderma mouse, we show that transplantation of MHC compatible, minor antigen mismatched bone marrow stromal/stem cells (BMSCs) play a role in the pathogenesis of fibrosis. Removal of donor BMSCs rescued mice from disease. Fre...

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Vydáno v:eLife
Hlavní autoři: Ogawa, Yoko, Morikawa, Satoru, Okano, Hideyuki, Mabuchi, Yo, Suzuki, Sadafumi, Yaguchi, Tomonori, Sato, Yukio, Mukai, Shin, Yaguchi, Saori, Inaba, Takaaki, Okamoto, Shinichiro, Kawakami, Yutaka, Tsubota, Kazuo, Matsuzaki, Yumi, Shimmura, Shigeto
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Developmental Biology and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739756/
https://ncbi.nlm.nih.gov/pubmed/26809474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09394
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