MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

Fibrosis of organs is observed in systemic autoimmune disease. Using a scleroderma mouse, we show that transplantation of MHC compatible, minor antigen mismatched bone marrow stromal/stem cells (BMSCs) play a role in the pathogenesis of fibrosis. Removal of donor BMSCs rescued mice from disease. Fre...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ogawa, Yoko, Morikawa, Satoru, Okano, Hideyuki, Mabuchi, Yo, Suzuki, Sadafumi, Yaguchi, Tomonori, Sato, Yukio, Mukai, Shin, Yaguchi, Saori, Inaba, Takaaki, Okamoto, Shinichiro, Kawakami, Yutaka, Tsubota, Kazuo, Matsuzaki, Yumi, Shimmura, Shigeto
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Developmental Biology and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739756/
https://ncbi.nlm.nih.gov/pubmed/26809474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09394
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados