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Antibody-dependent cellular cytotoxicity (ADCC) activity of a novel anti-PD-L1 antibody avelumab (MSB0010718C) on human tumor cells

Several anti-PD1/PD-L1 monoclonal antibodies (MAb) are currently providing evidence of clinical benefit in subsets of cancer patients. The mode of action of these MAbs is to inhibit PD1 on immune cells interacting with PD-L1 on tumor cells. These MAbs are either designed or engineered to eliminate a...

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Bibliografische gegevens
Gepubliceerd in:Cancer Immunol Res
Hoofdauteurs: Boyerinas, Benjamin, Jochems, Caroline, Fantini, Massimo, Heery, Christopher R., Gulley, James L., Tsang, Kwong Yok, Schlom, Jeffrey
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739754/
https://ncbi.nlm.nih.gov/pubmed/26014098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0059
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