GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion

The NF-E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway plays a critical role in protecting against oxidative stress in brain ischemia and reperfusion injury. Glycogen synthase kinase 3β (GSK-3β) may play a critical role in regulating Nrf2 in a Kelch-like ECH-associated protein...

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Udgivet i:Sci Rep
Main Authors: Chen, Xi, Liu, Yuanling, Zhu, Jin, Lei, Shipeng, Dong, Yuan, Li, Lingyu, Jiang, Beibei, Tan, Li, Wu, Jingxian, Yu, Shanshan, Zhao, Yong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738318/
https://ncbi.nlm.nih.gov/pubmed/26838164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20196
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