Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T Cell Mediated Tumor Control in the Genital Tract

PURPOSE: Two viral oncoproteins, E6 and E7, are expressed in all human papillomavirus (HPV)-infected cells, from initial infection in the genital tract to metastatic cervical cancer. Intramuscular vaccination of women with high grade cervical intraepithelial neoplasia (CIN2/3) twice with a naked DNA...

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Publicado no:Clin Cancer Res
Main Authors: Sun, Yun-Yan, Peng, Shiwen, Han, Liping, Qiu, Jin, Song, Liwen, Tsai, Yachea, Yang, Benjamin, Roden, Richard B.S., Trimble, Cornelia L., Hung, Chien-Fu, Wu, T-C
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738102/
https://ncbi.nlm.nih.gov/pubmed/26420854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0234
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