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Personalizing cardiac regenerative therapy: at the heart of Pim1 kinase

During cardiac aging, DNA damage and environmental stressors contribute to telomeric shortening and human cardiac progenitor cells acquire a senescent phenotype that leads to decreased stem cell function. Reversion of this phenotype through genetic modification is essential to advance regenerative t...

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Detalhes bibliográficos
Publicado no:Pharmacol Res
Main Authors: Samse, Kaitlen, Hariharan, Nirmala, Sussman, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738091/
https://ncbi.nlm.nih.gov/pubmed/26563999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2015.11.001
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