Generation and characterization of non-competitive furin-inhibiting nanobodies

The PC (proprotein convertase) furin cleaves a large variety of proproteins and hence plays a major role in many pathologies. Therefore furin inhibition might be a good strategy for therapeutic intervention, and several furin inhibitors have been generated, although none are entirely furin-specific....

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Publicado en:Biochem J
Autores principales: Zhu, Jingjing, Declercq, Jeroen, Roucourt, Bart, Ghassabeh, Gholamreza H., Meulemans, Sandra, Kinne, Jörg, David, Guido, Vermorken, Alphons J. M., Van de Ven, Wim J. M., Lindberg, Iris, Muyldermans, Serge, Creemers, John W. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737579/
https://ncbi.nlm.nih.gov/pubmed/22920187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120537
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