Aneuploidy-Dependent Massive Deregulation of the Cellular Transcriptome and Apparent Divergence of the Wnt/β-catenin Signaling Pathway in Human Rectal Carcinomas

To identify genetic alterations underlying rectal carcinogenesis, we used global gene expression profiling of a series of 17 locally advanced rectal adenocarcinomas and 20 normal rectal mucosa biopsies on oligonucleotide arrays. A total of 351 genes were differentially expressed (P < 1.0e–7) betw...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Grade, Marian, Ghadimi, B. Michael, Varma, Sudhir, Simon, Richard, Wangsa, Danny, Barenboim-Stapleton, Linda, Liersch, Torsten, Becker, Heinz, Ried, Thomas, Difilippantonio, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737482/
https://ncbi.nlm.nih.gov/pubmed/16397240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-05-2533
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