Internalization of Rituximab and the Efficiency of B Cell Depletion in Rheumatoid Arthritis and Systemic Lupus Erythematosus

OBJECTIVE: Rituximab, a type I anti‐CD20 monoclonal antibody (mAb), induces incomplete B cell depletion in some patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), thus contributing to a poor clinical response. The mechanisms of this resistance remain elusive. The purpose...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Reddy, Venkat, Cambridge, Geraldine, Isenberg, David A., Glennie, Martin J., Cragg, Mark S., Leandro, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Rheumatoid Arthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737120/
https://ncbi.nlm.nih.gov/pubmed/25916583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39167
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