Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells

BACKGROUND: Granzyme B (GrB) is a serine protease, traditionally known as expressed by cytotoxic lymphocytes to induce target cell apoptosis. However, it is emerging that GrB, being also produced by a variety of normal and neoplastic cells and potentially acting on multiple targets, might represent...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: D’Eliseo, Donatella, Di Rocco, Giuliana, Loria, Rossella, Soddu, Silvia, Santoni, Angela, Velotti, Francesca
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736710/
https://ncbi.nlm.nih.gov/pubmed/26830472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0302-6
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