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Colorectal Delivery and Retention of PEG-Amprenavir-Bac7 Nanoconjugates - Proof of Concept for HIV Mucosal Pre-Exposure Prophylaxis

Local delivery of anti-HIV drugs to the colorectal mucosa, a major site of HIV replication, and their retention within mucosal tissue would allow for a reduction in dose administered, reduced dosing frequency and minimal systemic exposure. The current report describes a mucosal Pre-Exposure Prophyla...

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Detalhes bibliográficos
Publicado no:Drug Deliv Transl Res
Main Authors: Samizadeh, Mahta, Zhang, Xiaoping, Gunaseelan, Simi, Nelson, Antoinette G., Palombo, Matthew S., Myers, Daniel R., Singh, Yashveer, Ganapathi, Usha, Szekely, Zoltan, Sinko, Patrick J
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736156/
https://ncbi.nlm.nih.gov/pubmed/26712122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13346-015-0269-4
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