Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility

In this study, we demonstrate that an E3-ubiquitin ligase associated with human X-linked intellectual disability, CUL4B, plays a crucial role in post-meiotic sperm development. Initially, Cul4b(Δ)/Y male mice were found to be sterile and exhibited a progressive loss in germ cells, thereby leading to...

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Udgivet i:Sci Rep
Main Authors: Lin, Chien-Yu, Chen, Chun-Yu, Yu, Chih-Hsiang, Yu, I-Shing, Lin, Shu-Rung, Wu, June-Tai, Lin, Ying-Hung, Kuo, Pao-Lin, Wu, Jui-Ching, Lin, Shu-Wha
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735749/
https://ncbi.nlm.nih.gov/pubmed/26832838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20227
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