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Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease
During chronic kidney disease (CKD) there is a dysregulation of extracellular matrix (ECM) homeostasis leading to renal fibrosis. Lysosomal proteases such as cathepsins (Cts) regulate this process in other organs, however, their role in CKD is still unknown. Here we describe a novel role for catheps...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4735715/ https://ncbi.nlm.nih.gov/pubmed/26831567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20101 |
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