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Treg activation defect in type 1 diabetes: correction with TNFR2 agonism
Activated T-regulatory cells (aTregs) prevent or halt various forms of autoimmunity. We show that type 1 diabetics (T1D) have a Treg activation defect through an increase in resting Tregs (rTregs, CD4(+)CD25(+)Foxp3(+)CD45RA) and decrease in aTregs (CD4(+)CD25(+)Foxp3(+)CD45RO) (n= 55 T1D, n=45 cont...
में बचाया:
| में प्रकाशित: | Clin Transl Immunology |
|---|---|
| मुख्य लेखकों: | , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2016
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4735064/ https://ncbi.nlm.nih.gov/pubmed/26900470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cti.2015.43 |
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