Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye

PURPOSE: By using hypoxia-inducible factor-1 alpha conditional knockout (HIF-1α CKO) mice and a dry eye (DE) mouse model, we aimed to determine the role played by delta-like ligand 4 (Dll4)/Notch signaling and HIF-1α in the lymphangiogenesis of lacrimal glands (LGs). METHODS: C57BL/6 mice were house...

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Pubblicato in:PLoS One
Autori principali: Min, Ji Hwan, Lee, Chul Hee, Ji, Yong Woo, Yeo, Areum, Noh, Hyemi, Song, Insil, Kim, Eung Kweon, Lee, Hyung Keun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734677/
https://ncbi.nlm.nih.gov/pubmed/26828208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147846
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