Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression

Marburg virus (MARV), a member of the filovirus family, causes severe hemorrhagic fever with up to 90% lethality. MARV matrix protein VP40 is essential for assembly and release of newly copied viruses and also suppresses immune signaling in the infected cell. Here we report the crystal structure of...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Oda, Shun-ichiro, Noda, Takeshi, Wijesinghe, Kaveesha J., Halfmann, Peter, Bornholdt, Zachary A., Abelson, Dafna M., Armbrust, Tammy, Stahelin, Robert V., Kawaoka, Yoshihiro, Saphire, Erica Ollmann
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Structure and Assembly
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733994/
https://ncbi.nlm.nih.gov/pubmed/26656687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01597-15
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