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Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression

Marburg virus (MARV), a member of the filovirus family, causes severe hemorrhagic fever with up to 90% lethality. MARV matrix protein VP40 is essential for assembly and release of newly copied viruses and also suppresses immune signaling in the infected cell. Here we report the crystal structure of...

詳細記述

保存先:
書誌詳細
出版年:J Virol
主要な著者: Oda, Shun-ichiro, Noda, Takeshi, Wijesinghe, Kaveesha J., Halfmann, Peter, Bornholdt, Zachary A., Abelson, Dafna M., Armbrust, Tammy, Stahelin, Robert V., Kawaoka, Yoshihiro, Saphire, Erica Ollmann
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733994/
https://ncbi.nlm.nih.gov/pubmed/26656687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01597-15
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