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Controlling low rates of cell differentiation through noise and ultrahigh feedback
Mammalian tissue size is maintained by slow replacement of de-differentiating and dying cells. For adipocytes, key regulators of glucose and lipid metabolism, the renewal rate is only 10% per year. We used computational modeling, quantitative mass spectrometry, and single-cell microscopy to show tha...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733388/ https://ncbi.nlm.nih.gov/pubmed/24948735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1252079 |
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