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Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding.

We describe a detailed mapping of the class II major histocompatibility complex (MHC) binding site using site-directed mutagenesis in conjunction with high-resolution CD4 structural data. Residues on all lateral surfaces of domain 1 and the neighboring portions of domain 2 participate in contacting...

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Bibliografische gegevens
Hoofdauteurs: Moebius, U, Pallai, P, Harrison, S C, Reinherz, E L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1993
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC47328/
https://ncbi.nlm.nih.gov/pubmed/8367491
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