Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding.

We describe a detailed mapping of the class II major histocompatibility complex (MHC) binding site using site-directed mutagenesis in conjunction with high-resolution CD4 structural data. Residues on all lateral surfaces of domain 1 and the neighboring portions of domain 2 participate in contacting...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Moebius, U, Pallai, P, Harrison, S C, Reinherz, E L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47328/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8367491/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.17.8259
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