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Enzymes for Pancreatic Islet Isolation Impact Chemokine-Production and Polarization of Insulin-Producing β-Cells with Reduced Functional Survival of Immunoisolated Rat Islet-Allografts as a Consequence

The primary aim of this study was to determine whether normal variations in enzyme-activities of collagenases applied for rat-islet isolation impact longevity of encapsulated islet grafts. Also we studied the functional and immunological properties of rat islets isolated with different enzyme prepar...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: de Vos, Paul, Smink, Alexandra M., Paredes, Genaro, Lakey, Jonathan R. T., Kuipers, Jeroen, Giepmans, Ben N. G., de Haan, Bart J., Faas, Marijke M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732769/
https://ncbi.nlm.nih.gov/pubmed/26824526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147992
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