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High Affinity Heme Binding to a Heme Regulatory Motif on the Nuclear Receptor Rev-erbβ Leads to Its Degradation and Indirectly Regulates Its Interaction with Nuclear Receptor Corepressor

Rev-erbα and Rev-erbβ are heme-binding nuclear receptors (NR) that repress the transcription of genes involved in regulating metabolism, inflammation, and the circadian clock. Previous gene expression and co-immunoprecipitation studies led to a model in which heme binding to Rev-erbα recruits nuclea...

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Pubblicato in:J Biol Chem
Autori principali: Carter, Eric L., Gupta, Nirupama, Ragsdale, Stephen W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732205/
https://ncbi.nlm.nih.gov/pubmed/26670607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.670281
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