A powerful score-based test statistic for detecting gene-gene co-association

BACKGROUND: The genetic variants identified by Genome-wide association study (GWAS) can only account for a small proportion of the total heritability for complex disease. The existence of gene-gene joint effects which contains the main effects and their co-association is one of the possible explanat...

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Udgivet i:BMC Genet
Main Authors: Xu, Jing, Yuan, Zhongshang, Ji, Jiadong, Zhang, Xiaoshuai, Li, Hongkai, Wu, Xuesen, Xue, Fuzhong, Liu, Yanxun
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731962/
https://ncbi.nlm.nih.gov/pubmed/26822525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12863-016-0331-3
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