α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli

OBJECTIVE: α/β-Hydrolase domain-6 (ABHD6) is a newly identified monoacylglycerol (MAG) lipase. We recently reported that it negatively regulates glucose stimulated insulin secretion (GSIS) in the β cells by hydrolyzing lipolysis-derived MAG that acts as a metabolic coupling factor and signaling mole...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Zhao, Shangang, Poursharifi, Pegah, Mugabo, Yves, Levens, Emily J., Vivot, Kevin, Attane, Camille, Iglesias, Jose, Peyot, Marie-line, Joly, Erik, Madiraju, S.R. Murthy, Prentki, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731734/
https://ncbi.nlm.nih.gov/pubmed/26909310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.09.012
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