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CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders
CYP24A1 (hereafter referred to as CYP24) enzymatic activity is pivotal in the inactivation of vitamin D metabolites. Basal renal and extrarenal CYP24 is usually low but is highly induced by its substrate 1,25-dihydroxyvitamin D. Unbalanced high and/or long-lasting CYP24 expression has been proposed...
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| Publicado en: | J Clin Invest |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4731193/ https://ncbi.nlm.nih.gov/pubmed/26784541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81928 |
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