Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain Antibodies

Clostridium difficile is the primary cause of nosocomial antibiotic-associated diarrhea in the Western world. The major virulence factors of C. difficile are two exotoxins, toxin A (TcdA) and toxin B (TcdB), which cause extensive colonic inflammation and epithelial damage manifested by episodes of d...

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Dettagli Bibliografici
Pubblicato in:Infect Immun
Autori principali: Andersen, Kasper Krogh, Strokappe, Nika M., Hultberg, Anna, Truusalu, Kai, Smidt, Imbi, Mikelsaar, Raik-Hiio, Mikelsaar, Marika, Verrips, Theo, Hammarström, Lennart, Marcotte, Harold
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730582/
https://ncbi.nlm.nih.gov/pubmed/26573738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00870-15
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