Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53

Metformin is known to alleviate hepatosteatosis by inducing 5’ adenosine monophosphate (AMP)-kinase-independent, sirtuin 1 (SIRT1)-mediated autophagy. Dysfunctional mitophagy in response to glucolipotoxicities might play an important role in hepatosteatosis. Here, we investigated the mechanism by wh...

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發表在:Int J Mol Sci
Main Authors: Song, Young Mi, Lee, Woo Kyung, Lee, Yong-ho, Kang, Eun Seok, Cha, Bong-Soo, Lee, Byung-Wan
格式: Artigo
語言:Inglês
出版: MDPI 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730363/
https://ncbi.nlm.nih.gov/pubmed/26784190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17010122
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