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Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53
Metformin is known to alleviate hepatosteatosis by inducing 5’ adenosine monophosphate (AMP)-kinase-independent, sirtuin 1 (SIRT1)-mediated autophagy. Dysfunctional mitophagy in response to glucolipotoxicities might play an important role in hepatosteatosis. Here, we investigated the mechanism by wh...
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| Izdano u: | Int J Mol Sci |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
MDPI
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4730363/ https://ncbi.nlm.nih.gov/pubmed/26784190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17010122 |
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