Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear. In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including one against HBV. Here we show, using transcriptional and cytometric profiling of whole blood collected before vaccination...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Fourati, Slim, Cristescu, Razvan, Loboda, Andrey, Talla, Aarthi, Filali, Ali, Railkar, Radha, Schaeffer, Andrea K., Favre, David, Gagnon, Dominic, Peretz, Yoav, Wang, I-Ming, Beals, Chan R., Casimiro, Danilo R., Carayannopoulos, Leonidas N., Sékaly, Rafick-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729923/
https://ncbi.nlm.nih.gov/pubmed/26742691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10369
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