Felty’s Syndrome Autoantibodies Bind to Deiminated Histones and Neutrophil Extracellular Chromatin Traps

OBJECTIVE: To test the hypothesis that autoantigen modifications by peptidylarginine deiminase type 4 (PAD-4) increase immunoreactivity. METHODS: We assembled sera from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Felty’s syndrome (FS), and antineutrophil cytoplasmic...

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Published in:Arthritis Rheum
Main Authors: Dwivedi, Nishant, Upadhyay, Jagriti, Neeli, Indira, Khan, Salar, Pattanaik, Debendra, Myers, Linda, Kirou, Kyriakos A., Hellmich, Bernhard, Knuckley, Bryan, Thompson, Paul R., Crow, Mary K., Mikuls, Ted R., Csernok, Elena, Radic, Marko
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729190/
https://ncbi.nlm.nih.gov/pubmed/22034172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33432
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