Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and reduction

BACKGROUND: Inefficient experimental designs are common in animal-based biomedical research, wasting resources and potentially leading to unreplicable results. Here we illustrate the intrinsic statistical power of split-plot designs, wherein three or more sub-units (e.g. individual subjects) differi...

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Bibliographic Details
Published in:BMC Med Res Methodol
Main Authors: Walker, Michael, Fureix, Carole, Palme, Rupert, Newman, Jonathan A., Ahloy Dallaire, Jamie, Mason, Georgia
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729181/
https://ncbi.nlm.nih.gov/pubmed/26817696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-016-0113-7
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