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Designing string-of-beads vaccines with optimal spacers

String-of-beads polypeptides allow convenient delivery of epitope-based vaccines. The success of a polypeptide relies on efficient processing: constituent epitopes need to be recovered while avoiding neo-epitopes from epitope junctions. Spacers between epitopes are employed to ensure this, but space...

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Publicat a:Genome Med
Autors principals: Schubert, Benjamin, Kohlbacher, Oliver
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728757/
https://ncbi.nlm.nih.gov/pubmed/26813686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0263-6
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