Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1

Aberrant gene expression within the hippocampus has recently been implicated in the pathogenesis of obesity-induced memory impairment. Whether a dysregulation of epigenetic modifications mediates this disruption in gene transcription has yet to be established. Here we report evidence of obesity-indu...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Heyward, Frankie D., Gilliam, Daniel, Coleman, Mark A., Gavin, Cristin F., Wang, Jing, Kaas, Garrett, Trieu, Richard, Lewis, John, Moulden, Jerome, Sweatt, J. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728728/
https://ncbi.nlm.nih.gov/pubmed/26818519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1934-15.2016
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