TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL

Translationally Controlled Tumor Protein (TCTP) is anti-apoptotic, key in development and cancer, however without the typical Bcl2 family members’ structure. Here we report that TCTP contains a BH3-like domain and forms heterocomplexes with Bcl-xL. The crystal structure of a Bcl-xL deletion variant-...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Thébault, Stéphanie, Agez, Morgane, Chi, Xiaoke, Stojko, Johann, Cura, Vincent, Telerman, Stéphanie B., Maillet, Laurent, Gautier, Fabien, Billas-Massobrio, Isabelle, Birck, Catherine, Troffer-Charlier, Nathalie, Karafin, Teele, Honoré, Joane, Senff-Ribeiro, Andrea, Montessuit, Sylvie, Johnson, Christopher M., Juin, Philippe, Cianférani, Sarah, Martinou, Jean-Claude, Andrews, David W., Amson, Robert, Telerman, Adam, Cavarelli, Jean
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728560/
https://ncbi.nlm.nih.gov/pubmed/26813996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19725
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars