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Diverse Mechanisms of Sp1-Dependent Transcriptional Regulation Potentially Involved in the Adaptive Response of Cancer Cells to Oxygen-Deficient Conditions

The inside of a tumor often contains a hypoxic area caused by a limited supply of molecular oxygen due to aberrant vasculature. Hypoxia-inducible factors (HIFs) are major transcription factors that are required for cancer cells to adapt to such stress conditions. HIFs, complexed with the aryl hydroc...

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Publicat a:Cancers (Basel)
Autors principals: Koizume, Shiro, Miyagi, Yohei
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728449/
https://ncbi.nlm.nih.gov/pubmed/26703734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers8010002
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