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Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker
BACKGROUND AND PURPOSE: Calcium‐activated chloride channels (CaCCs) play varied physiological roles and constitute potential therapeutic targets for conditions such as asthma and hypertension. TMEM16A encodes a CaCC. CaCC pharmacology is restricted to compounds with relatively low potency and poorly...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4728427/ https://ncbi.nlm.nih.gov/pubmed/26562072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13381 |
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