Characterization of the Oxidative Degradation Product of Darunavir by LC-MS/MS

A rapid, selective, and reliable LC-MS(n) method has been developed and validated for the isolation and structural characterization of the degradation product of darunavir (DRV). DRV, an HIV-1 protease inhibitor, was subjected to intrinsic oxidative stress conditions using 30% hydrogen peroxide and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Pharm
Main Authors: Yamjala, Karthik, Atukuri, Jeevitha, Nagappan, Krishnaveni, Halekote Shivaraju, Nivedeetha, Subramania Nainar, Meyyanathan
Format: Artigo
Jezik:Inglês
Izdano: The Austrian Journal of Pharmaceutical Sciences 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727738/
https://ncbi.nlm.nih.gov/pubmed/26839843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3797/scipharm.1505-10
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