Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells

Polyphyllin VII (PP7), a pennogenyl saponin isolated from Rhizoma Paridis, exhibited strong anticancer activities in various cancer types. Previous studies found that PP7 induced apoptotic cell death in human hepatoblastoma cancer (HepG2) cells. In the present study, we investigated whether PP7 coul...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Chao, Jia, Xuejing, Wang, Kai, Bao, Jiaolin, Li, Peng, Chen, Meiwan, Wan, Jian-Bo, Su, Huanxing, Mei, Zhinan, He, Chengwei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726701/
https://ncbi.nlm.nih.gov/pubmed/26808193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147405
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