A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics

The tropomyosin family of proteins form end-to-end polymers along the actin filament. Tumour cells rely on specific tropomyosin-containing actin filament populations for growth and survival. To dissect out the role of tropomyosin in actin filament regulation we use the small molecule TR100 directed...

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Udgivet i:Sci Rep
Main Authors: Bonello, Teresa T., Janco, Miro, Hook, Jeff, Byun, Alex, Appaduray, Mark, Dedova, Irina, Hitchcock-DeGregori, Sarah, Hardeman, Edna C., Stehn, Justine R., Böcking, Till, Gunning, Peter W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726228/
https://ncbi.nlm.nih.gov/pubmed/26804624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19816
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