Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification

Pathologic extraskeletal bone formation, or heterotopic ossification (HO), occurs following mechanical trauma, burns, orthopedic operations, and in patients with hyperactivating mutations of the type I bone morphogenetic protein receptor ACVR1 (Activin type 1 receptor). Extraskeletal bone forms thro...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Agarwal, Shailesh, Loder, Shawn, Brownley, Cameron, Cholok, David, Mangiavini, Laura, Li, John, Breuler, Christopher, Sung, Hsiao H., Li, Shuli, Ranganathan, Kavitha, Peterson, Joshua, Tompkins, Ronald, Herndon, David, Xiao, Wenzhong, Jumlongras, Dolrudee, Olsen, Bjorn R., Davis, Thomas A., Mishina, Yuji, Schipani, Ernestina, Levi, Benjamin
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725488/
https://ncbi.nlm.nih.gov/pubmed/26721400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515397113
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