Reversal of morphine-induced cell-type–specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement

Drug-evoked plasticity at excitatory synapses on medium spiny neurons (MSNs) of the nucleus accumbens (NAc) drives behavioral adaptations in addiction. MSNs expressing dopamine D1 (D1R-MSN) vs. D2 receptors (D2R-MSN) can exert antagonistic effects in drug-related behaviors, and display distinct alte...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hearing, Matthew C., Jedynak, Jakub, Ebner, Stephanie R., Ingebretson, Anna, Asp, Anders J., Fischer, Rachel A., Schmidt, Clare, Larson, Erin B., Thomas, Mark John
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725472/
https://ncbi.nlm.nih.gov/pubmed/26739562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519248113
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