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Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex

Neuronal persistent activity has been primarily assessed in terms of electrical mechanisms, without attention to the complex array of molecular events that also control cell excitability. We developed a multiscale neocortical model proceeding from the molecular to the network level to assess the con...

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Publicado en:Neuroscience
Autores principales: Neymotin, Samuel A., McDougal, Robert A., Bulanova, Anna S., Zeki, Mustafa, Lakatos, Peter, Terman, David, Hines, Michael L., Lytton, William W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724569/
https://ncbi.nlm.nih.gov/pubmed/26746357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2015.12.043
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