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Dietary Indoles Suppress Delayed-Type Hypersensitivity by Inducing a Switch from Pro-inflammatory Th17 cells to Anti-inflammatory Tregs through Regulation of microRNA

Aryl hydrocarbon receptor (AhR) has been shown to have profound influence on T cell differentiation and use of distinct AhR ligands has shown that while some ligands induce Tregs, others induce Th17 cells. In the current study, we tested the ability of dietary AhR ligands (indole-3-carbinol; I3C and...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Singh, Narendra P., Singh, Udai P., Rouse, Michael, Zhang, Jiajia, Chatterjee, Saurabh, Nagarkatti, Prakash S., Nagarkatti, Mitzi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724476/
https://ncbi.nlm.nih.gov/pubmed/26712945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501727
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