Spatiotemporal release of BMP-2 and VEGF enhances osteogenic and vasculogenic differentiation of human mesenchymal stem cells and endothelial colony-forming cells co-encapsulated in a patterned hydrogel

Reconstruction of large bone defects is limited by insufficient vascularization and slow bone regeneration. The objective of this work was to investigate the effect of spatial and temporal release of recombinant human bone morphogenetic protein-2 (BMP2) and vascular endothelial growth factor (VEGF)...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Barati, Danial, Shariati, Seyed Ramin Pajoum, Moeinzadeh, Seyedsina, Melero-Martin, Juan M., Khademhosseini, Ali, Jabbari, Esmaiel
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724464/
https://ncbi.nlm.nih.gov/pubmed/26721447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2015.12.031
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