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Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid

Oxidation of a protein cysteine thiol to sulfenic acid, termed S-sulfenylation, is a reversible post-translational modification that plays a crucial role in regulating protein function and is correlated with disease states. The majority of reaction-based small molecule and immunochemical probes used...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Gupta, Vinayak, Carroll, Kate S.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724439/
https://ncbi.nlm.nih.gov/pubmed/26819701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc02569a
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