Differential expression of vascular endothelial growth factor A, its receptors VEGFR-1, -2, and -3 and co-receptors neuropilin-1 and -2 does not predict bevacizumab response in human astrocytomas

BACKGROUND: A major hallmark of malignant progression in human astrocytomas is the formation of new blood vessels. Antiangiogenic therapy using the anti-vascular endothelial growth factor (VEGF)-antibody bevacizumab leads to increased progression-free survival in glioblastoma patients but does not i...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Baumgarten, Peter, Blank, Anna-Eva, Franz, Kea, Hattingen, Elke, Dunst, Maika, Zeiner, Pia, Hoffmann, Katharina, Bähr, Oliver, Mäder, Lisa, Goeppert, Benjamin, Machein, Marcia, Seifert, Volker, Steinbach, Joachim P., Plate, Karl H., Harter, Patrick N., Mittelbronn, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724185/
https://ncbi.nlm.nih.gov/pubmed/26627848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov288
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