Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols

Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS) using a large number of blood specimens from multiple biobanks and/or cohorts. Here we show that pre-analytical procedures involved in DNA collection can induce systematic bias in the D...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Shiwa, Yuh, Hachiya, Tsuyoshi, Furukawa, Ryohei, Ohmomo, Hideki, Ono, Kanako, Kudo, Hisaaki, Hata, Jun, Hozawa, Atsushi, Iwasaki, Motoki, Matsuda, Koichi, Minegishi, Naoko, Satoh, Mamoru, Tanno, Kozo, Yamaji, Taiki, Wakai, Kenji, Hitomi, Jiro, Kiyohara, Yutaka, Kubo, Michiaki, Tanaka, Hideo, Tsugane, Shoichiro, Yamamoto, Masayuki, Sobue, Kenji, Shimizu, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4723336/
https://ncbi.nlm.nih.gov/pubmed/26799745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147519
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