A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane in Escherichia coli

Increasing antibacterial resistance presents a major challenge in antibiotic discovery. One attractive target in Gram-negative bacteria is the unique asymmetric outer membrane (OM), which acts as a permeability barrier that protects the cell from external stresses, such as the presence of antibiotic...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Urfer, Matthias, Bogdanovic, Jasmina, Lo Monte, Fabio, Moehle, Kerstin, Zerbe, Katja, Omasits, Ulrich, Ahrens, Christian H., Pessi, Gabriella, Eberl, Leo, Robinson, John A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722468/
https://ncbi.nlm.nih.gov/pubmed/26627837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.691725
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