Structural and Functional Characterization of the PaaI Thioesterase from Streptococcus pneumoniae Reveals a Dual Specificity for Phenylacetyl-CoA and Medium-chain Fatty Acyl-CoAs and a Novel CoA-induced Fit Mechanism

PaaI thioesterases are members of the TE13 thioesterase family that catalyze the hydrolysis of thioester bonds between coenzyme A and phenylacetyl-CoA. In this study we characterize the PaaI thioesterase from Streptococcus pneumoniae (SpPaaI), including structural analysis based on crystal diffracti...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Khandokar, Yogesh B., Srivastava, Parul, Sarker, Subir, Swarbrick, Crystall M. D., Aragao, David, Cowieson, Nathan, Forwood, Jade K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722464/
https://ncbi.nlm.nih.gov/pubmed/26538563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677484
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