From Single Variants to Protein Cascades: MULTISCALE MODELING OF SINGLE NUCLEOTIDE VARIANT SETS IN GENETIC DISORDERS

Understanding the role of genetics in disease has become a central part of medical research. Non-synonymous single nucleotide variants (nsSNVs) in coding regions of human genes frequently lead to pathological phenotypes. Beyond single variations, the individual combination of nsSNVs may add to patho...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Mueller, Sabine C., Sommer, Björn, Backes, Christina, Haas, Jan, Meder, Benjamin, Meese, Eckart, Keller, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Computational Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722441/
https://ncbi.nlm.nih.gov/pubmed/26601959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.695247
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